The articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit "trained immunity" for the development of new ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic. In the years that followed, other groups ...

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in ...

Innate immunity constitutes the body’s first line of defence against invading pathogens. This ancient, evolutionarily conserved system is activated within minutes of encountering foreign agents, ...

Our latest Focus Issue looks at what we’ve learnt over the past decade and what’s next for the field of trained immunity.

The innate immune system serves as the body's first line of defence, rapidly detecting and responding to external pathogens and internal damage. Recent advances in the field have highlighted the ...

Activates innate and adaptive immune pathways, including increased antigen-experienced CD8 + T cells, activated CD4 + T cells, and Ki67 + NK cells. Induces immune-regulating chemokines CXCL9 and ...

Researchers from Penn’s School of Dental Medicine discovered that training the innate immune system may lead to increased bone loss in inflammatory conditions such as periodontitis and arthritis.

Training Non-Oncologist Healthcare Providers to Manage Oral Endocrine Therapy for Breast Cancer The immune system of living being has evolved via the action of immune defense mechanism by utilizing ...

SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may ...

All of these questions deserve urgent exploration. Unfortunately, the discovery comes at a particularly difficult moment for ...